Ellen Pompeo is an American actress best known for her title role as Dr. Meredith Grey on the medical comedy-drama television series Grey's Anatomy.
Sandra Oh is a Canadian actress best known for her role as Dr. Cristina Yang in the television drama series Grey's Anatomy and for her roles in the feature films Under the Tuscan Sun (2003) and Sideways (2004).
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Isobel "Izzie" Stevens
Katherine Heigl is an American actress and former fashion model best known for her role as Dr. Izzie Stevens in the television medical drama series Grey's Anatomy, from 2005-2010.
Justin Chambers is an American actor and former Calvin Klein male fashion model best known for his role as Dr. Alex Karev in the hospital drama television series Grey's Anatomy.
T.R. Knight is an American actor best known for his role as Dr. George O'Malley on the television medical drama Grey's Anatomy, from 2005-2009.
Chandra Wilson is an American actress best known for her role as Dr. Miranda Bailey on the television drama series Grey's Anatomy.
James Pickens, Jr. is an American actor best known for his starring roles as chief of surgery Dr. Richard Webber on the television drama series Grey's Anatomy and as Assistant Director Alvin Kersh on The X-Files, from 1998-2002.
Isaiah Washington is an American actor best known for his role as Dr. Preston Burke on the television dramedy Grey's Anatomy, from 2005-2007.
Patrick Dempsey is an American actor best known for his role as neurosurgeon Dr. Derek Shepherd on the medical drama Grey's Anatomy.
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Dr. Addison Montgomery
Kate Walsh is an American actress best known for her starring role as Dr. Addison Montgomery on the medical drama Grey's Anatomy and its spin-off series, Private Practice, from 2007-2013.
Sara Ramirez is a Mexican-American actress and singer best known for her role as Dr. Callie Torres in the television dramedy Grey's Anatomy.
Eric Dane is an American actor best known for his role as Dr. Mark Sloan in the medical drama series Grey's Anatomy, from 2005-2012.
Chyler Leigh is an American actress best known for her starring role as Dr. Lexie Grey in the medical comedy-drama television series Grey's Anatomy.
Brooke Smith is an American actress best known for her television roles as Dr. Kate Switzer in Crossing Jordan (2007) and as Dr. Erica Hahn in Grey's Anatomy, from 2006-2008.
Kevin McKidd is a Scottish actor best known for his television roles as Lucius Vorenus on Rome (2005-2007) and as time traveler Dan Vasser on Journeyman, in 2007
Jessica Capshaw is an American actress best known for her role as attorney Jamie Stringer on the television legal drama The Practice, from 2002-2004
Kim Raver is an American actress best known for her television roles as Kim Zambrano on Third Watch (1999-2005), as Audrey Raines on 24 (2004-2007) and as Nico Reilly on Lipstick Jungle, from 2008-2009
Jesse Williams is an American actor and model best known for his role as Lena's boyfriend Leo in the film sequel The Sisterhood of the Traveling Pants 2 (2008) and as Dr
Sarah Drew is an American actress best known for her role as Hannah Rogers in the television drama series Everwood, from 2004-2006
Camilla Luddington is an English actress best known for her starring role as Kate Middleton in the made-for-television movie William & Kate, in 2011
Gaius Charles is an American actor best known for his role as the star running back Brian 'Smash' Williams in the football drama Friday Night Lights
Jerrika Hinton is an American actress best known for her recurring role as Dr. Stephanie Edwards in the medical drama television series Grey's Anatomy.
Tessa Ferrer is an American actress best known for her recurring role as Dr. Leah Murphy in the medical drama television series Grey's Anatomy.
Caterina Scorsone is a Canadian actress best known for her role as Jess Mastriani, a young woman who sees missing persons in visions, in the supernatural television series Missing, from 2003-2006
Kelly McCreary is an American actress best known for her starring role as first-year surgical intern Tyra Dupre, who quickly befriends Emily and also has the misfortune of being the daughter of the chief resident, in the medical drama television series Emily Owens, M.D.
Martin Henderson is a New Zealand actor best known for his starring role as Dr
Giacomo Gianniotti is a Canadian actor best known for his role as Dr. Andrew DeLuca on the medical drama television series Grey's Anatomy.
Jason George (also credited as Jason Winston George) is an American actor best known for his starring role as J.T. Hunter in the television sitcom Eve, from 2003-2006.